Dr Nathan Holmes

Dr Nathan Holmes

Dr Nathan Holmes

ARC DECRA Fellow

Contact details

Phone: (02) 9385 3523
Email: Dr Nathan Holmes
Fax: (02) 9385 3641

Office: Mathews, Room 608

Research Summary

I use animal models to study the behavioural and neurobiological substrates of attention, learning and memory. I am interested in the factors which regulate these processes in a normal brain, cause disturbances to these processes in a diseased brain, and the implications of these disturbances for disorders like post-traumatic stress (PTSD). In one line of inquiry, I study how basic information is processed in the brain, and how motivational states (like fear) change the way that information is processed. In a second line of inquiry, I study how the brain deals with contrasting information, and the role of context in processing this information.

Publications

Journal Publications

Bae, S. E., Holmes, N. M., & Westbrook. R. F. (2015). False context fear memory in rats. Learning & Memory, (in press).

Campbell-Smith, E. J., Holmes, N. M., Lingawi, N. W., Panayi, M. C., & Westbrook, R. F. (2015). Oxytocin signalling in basolateral and central amygdala nuclei differentially regulates the acquisition, expression and extinction of context conditioned fear in rats. Learning & Memory, 22(5), 245-57.

Hart, G., Holmes, N. M., Harris, J. A., & Westbrook, R. F. (2014). Benzodiazepine administration prevents the use of error-correction mechanisms during fear extinction. Learning & Behavior, 42(4), 383-97.

Holmes, N. M., & Westbrook, R. F. (2014). Appetitive context conditioning proactively, but transiently, interferes with expression of counter-conditioned context fear. Learning & Memory, 21(11), 597-605.

Holmes, N. M., Cai, S. Y., Lay, B. P. P., Watts, N. R., & Westbrook, R. F. (2014). Extinguished second-order fear responses are renewed but not reinstated. Journal of Experimental Psychology: Animal Learning & Cognition, 40(4), 440-458.

Holmes, N. M., Griffiths, O., & Westbrook, R. F. (2014). The influence of partner cues on extinction of causal judgments in people. Learning & Behavior, 42(3), 289-303.

 Clemens, K. J., Castino, M. R., Cornish, J. L., Goodchild, A. K., & Holmes, N. M. (2014). Behavioral and neural substrates of habit formation in rats intravenously self-administering nicotine. Neuropsychopharmacology, 39(11), 2584-93.

Holmes, N. M., South, T., Martire, S. I., Westbrook, R. F., & Morris, M. J. (2014). Rats eat a cafeteria-style diet to excess, but eat smaller amounts and less frequently when tested with chow. PLoS ONE, 9(4), e93506.

Holmes, N. M., & Westbrook, R. F. (2014). ABA renewal is greater when extinction occurs in the same context as cue pre-exposure. Journal of Experimental Psychology: Animal Learning & Cognition, 40(3), 369-79.

Martire, S. I., Maniam, J., South, T., Holmes, N. M., Westbrook, R. F., & Morris, M. J. (2014). Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress. Behavioural Brain Research, 265, 132-41.

Holmes, N. M., Parkes, S. L., Killcross, A. S., & Westbrook, R. F. (2013). The basolateral amygdala is critical for learning about neutral stimuli in the presence of danger, and the perirhinal cortex is critical in the absence of danger. Journal of Neuroscience, 33(32), 13112-25.

Holmes, N. M., & Fam, J. (2013). How does dopamine release in the nucleus accumbens core relate to encoding of a Pavlovian incentive stimulus? Journal of Neuroscience, 33(25), 10191-2.

Holmes, N. M., & Westbrook, R. F. Extinction of reinstated or ABC renewed fear responses renders them resistant to subsequent ABA renewal. Journal of Experimental Psychology: Animal Behavior Processes, 39(3), 208-220.

Martire, S. I., Holmes, N. M., Westbrook, R. F., & Morris, M. J. (2013). Altered feeding patterns in rats exposed to a cafeteria diet: increased snacking and its implications for development of obesity. PLoS ONE, DOI: 10.1371/journal.pone.0060407.

Rosenberg, H., Holmes, N. M., Harris, J. A., & Westbrook, R. F. (2011). Pre-exposure enhances recovery of conditioned responding after extinction. Learning & Behavior, 39(3), 212-23.

Holmes, N. M., & Clemens, K. J. (2011). Multiple interpretations of cocaine-seeking behaviour after prolonged self-administration training. Journal of Neuroscience, 31(11), 3935-6.

Holmes, N. M., Marchand, A. R., & Coutureau, E. (2010). Pavlovian to instrumental transfer: A neurobehavioural perspective. Neuroscience & Biobehavioral Reviews, 34(8), 1277-95.

Holtzman, O., Siette, J., Holmes, N. M., & Westbrook, R. F. (2010). Additional exposures reverse the latent inhibitory effects of recent and remote exposures. Journal of Experimental Psychology: Animal Behavior Processes, 36(3), 368-80.

Holmes, N. M., & Harris, J. A. (2009). The loss of latent inhibition across compound conditioning. Journal of Experimental Psychology: Animal Behavior Processes, 35(3), 328-39.

 Book Chapters

Holmes, N. M. &Harris, J. A. (2010). Latent inhibition. In Attention and Associative Learning, Le Pelley, M., & Mitchell, C. (Eds.). Oxford University Press.

Awards, Fellowships & Grants

2015-17  Australian Research Council Discovery Early Career Research Award ($AU375,000)

2015-17  National Health and Medical Research Council Project Grant ($AU390,000)

2009-10  Bourse du Victor Segalen Université de Bordeaux 2 ($AU10,000)

2005-09  Australian Postgraduate Award ($AU75,000)

Affiliations & Memberships

Society for Neuroscience (SfN)

Australian Neuroscience Society (ANS)

French Neuroscience Society

Australian Learning Group (ALG)